Propulsion simulator for magnetically-suspended wind tunnel models

The objective of phase two of a current investigation sponsored by NASA Langley Research Center is to demonstrate the measurement of aerodynamic forces/moments, including the effects of exhaust gases, in magnetic suspension and balance system (MSBS) wind tunnels. Two propulsion simulator models are being developed: a small-scale and a large-scale unit, both employing compressed, liquified carbon dioxide as propellant. The small-scale unit was designed, fabricated, and statically-tested at Physical Sciences Inc. (PSI). The large-scale simulator is currently in the preliminary design stage. The small-scale simulator design/development is presented, and the data from its static firing on a thrust stand are discussed. The analysis of this data provides important information for the design of the large-scale unit. A description of the preliminary design of the device is also presented

Molecules in the transition disk orbiting T Cha

We seek to establish the presence and properties of gas in the circumstellar disk orbiting T Cha, a nearby (d~110 pc), relatively evolved (age ~5-7 Myr) yet actively accreting 1.5 Msun T Tauri star. We used the APEX 12 m radiotelescope to search for submillimeter molecular emission from the T Cha disk, and we reanalyzed archival XMM-Newton spectroscopy of T Cha to ascertain the intervening absorption due to disk gas along the line of sight to the star (N_H). We detected submillimeter rotational transitions of 12CO, 13CO, HCN, CN and HCO+ from the T Cha disk. The 12CO line appears to display a double-peaked line profile indicative of Keplerian rotation. Analysis of the CO emission line data indicates that the disk around T Cha has a mass (M_disk,H_2 = 80 M_earth) similar to, but more compact (R_disk, CO~80 AU) than, other nearby, evolved molecular disks (e.g. V4046 Sgr, TW Hya, MP Mus) in which cold molecular gas has been previously detected. The HCO+/13CO and HCN/13CO, line ratios measured for T Cha appear similar to those of other evolved circumstellar disks (i.e. TW Hya and V4046 Sgr), while the CN/13CO ratio appears somewhat weaker. Analysis of the XMM-Newton data shows that the atomic absorption $N_H$ toward T Cha is 1-2 orders of magnitude larger than toward the other nearby T Tauri with evolved disks. Furthermore, the ratio between atomic absorption and optical extinction N_H/A_V toward T Cha is higher than the typical value observed for the interstellar medium and young stellar objects in the Orion Nebula Cluster. This may suggest that the fraction of metals in the disk gas is higher than in the interstellar medium. Our results confirm that pre-main sequence stars older than ~5 Myr, when accreting, retain cold molecular disks, and that those relatively evolved disks display similar physical and chemical properties.Comment: Accepted for publication on A&

Susceptibility testing of colistin for acinetobacter baumannii: How far are we from the truth?

Acinetobacter baumannii is involved in life-threatening nosocomial infections, mainly in the intensive care units (ICUs), and often colistin may represent the last therapeutic opportunity. The susceptibility to colistin of 51 epidemiologically typed A. baumannii strains isolated in 2017 from clinical samples of patients hospitalized in the ICU of a tertiary care academic hospital was investigated. All isolates were carbapenem-resistant due to the presence of the blaOXA-23 gene in sequence group 1 (international clonal lineage II) and sequence group 4 (related to international clonal lineage II) isolates, and to the blaOXA-24/40 gene in sequence group 2 (international clonal lineage I) isolates. Vitek®2, agar diffusion, and broth microdilution tests showed major discordancy (≥2 dilution factors) in the minimum inhibitory concentration (MIC) values for colistin in 24 out of 51 isolates, resulting in erroneous reporting of qualitative susceptibility data for eight isolates. In growth kinetics experiments in the presence of colistin, five isolates grew with drug concentrations above the susceptibility breakpoint when incubated for >12 h, and three isolates showed the presence of heteroresistant subpopulations. This study highlights that the high frequency of isolation of carbapenem-resistant A. baumannii strains in high-risk infectious wards requires an accurate application of methods for detecting susceptibility to antibiotics, in particular to colistin, so as to ensure a correct therapeutic approach

Neural Network Pattern Recognition Experiments Toward a Fully Automatic Detection of Anomalies in InSAR Time Series of Surface Deformation

We present a neural network-based method to detect anomalies in time-dependent surface deformation fields given a set of geodetic images of displacements collected from multiple viewing geometries. The presented methodology is based on a supervised classification approach using combinations of line of sight multitemporal, multi-geometry interferometric synthetic aperture radar (InSAR) time series of displacements. We demonstrate this method with a set of 170 million time series of surface deformation generated for the entire Italian territory and derived from ERS, ENVISAT, and COSMO-SkyMed Synthetic Aperture Radar satellite constellations. We create a training dataset that has been compared with independently validated data and current state-of-the-art classification techniques. Compared to state-of-the-art algorithms, the presented framework provides increased detection accuracy, precision, recall, and reduced processing times for critical infrastructure and landslide monitoring. This study highlights how the proposed approach can accelerate the anomalous points identification step by up to 147 times compared to analytical and other artificial intelligence methods and can be theoretically extended to other geodetic measurements such as GPS, leveling data, or extensometers. Our results indicate that the proposed approach would make the anomaly identification post-processing times negligible when compared to the InSAR time-series processing

FROM EPIGENETICS TO ANTI-DOPING APPLICATION: A NEW TOOL OF DETECTION

Eukaryotic genomes transcribe up to 90% of the genomic DNA but only 1\u20132% of these transcripts encode for proteins, whereas the vast majority are transcribed as non-coding RNAs (ncRNAs). They are divided into short ncRNA, particularly microRNA (miRNA) and small interference RNA (siRNA), and long ncRNAs. Noteworthy, they are unexpectedly stable since they are protected from degradation through different mechanisms: package in exosomes/microvesicles structures, in apoptotic bodies, in HDL lipoprotein, or by RNA binding proteins. For several years already, biomarkers have been used to detect biological disease; in the last years, a requirement appeared to find some of them to unearth the signs of doping. The potential of ncRNAs as a biological candidate is strongly debated and it seems to have become the right tool in the anti-doping hands. In the recent years, the next-generation sequencing (NGS) technology was used by the World Anti-Doping Agency to draft the athlete biological passport (ABP), measuring the circulating miRNAs and applying these new biomarkers in anti-doping. NGS technology does not require any prior knowledge of ncRNAs, but the limit to employ this biomarker to detect performance-enhancing drug use must consider the intrinsic and extrinsic factors that might affect measurements. Key words: pbiomarkers, doping, HDL, ncRNA, exosom

MULTIPLE SCLEROSIS: PHYSICAL ACTIVITY AND WELL-BEING

Multiple sclerosis (MS) is a chronic disease that affects central nervous system (CNS) \u2013 coexists in brain, spinal cord and optic nerves. It can process in three different courses: remitting, progressive and progressive-relapsing. Although there is still no cure for MS, effective strategies are available to modify the disease course, reduce number of relapses, rate of progressions and development of new lesions. Nowadays, moderate physical performance is strongly recommended: besides having positive effects on the body, it can have a positive effect on the psychophysical wellbeing. Essentially there are 3 types of training protocols: aerobic (endurance training), strength training (resistance training) and combined training. The majority of the studies suggests that regular physical activity can improve fatigue, depression and quality of life in people with MS, however most of the researchers worked without any guidelines for physical activity adapted to the MS, which are still under review by the scientific communit

Search for periodicities near 59 s in the COS-B gamma-ray data of 2CG195+04 (Geminga)

The COS-B data relating to five observations in the general direction of Geminga, spanning 6.7 years, were searched for pulsation near 59 s. The SAS-2 indication is not confirmed. An indication of a 59 s pulsation in the gamma ray emission from 2CG195+04 (Geminga) was reported. Early analysis of COS-B data supported the result while later improved statistics did not confirm it. Subsequently, detection of a 59 s pulsation in the emission from the direction of Geminga at ultra high gamma and X-rays was reported. Geminga was identified with the X-ray source 1E0630+128. The final COS-B data on Geminga which was observed five times for a total of 214 days are reported